Where I Wander

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#kitten #aww

#kitten #aww

Pipsqueak taking a nap in my hair. #kitten #snuggle #aww

Pipsqueak taking a nap in my hair. #kitten #snuggle #aww

Taking over the couch! #kittens #cute #aww

Taking over the couch! #kittens #cute #aww

(Source: bloeien)

Think Seeing A Little Male Nudity On TV Is Too Explicit? Then ... It's Time To Hear The Hard Truth.

my-wanton-self:

sheiswanton:

i giggled, i cheered, & i giggled some more.

Definitely time for some Man Tube on my Boob Tube or We’ve got a Boner to Pick with You. heh-heh.  These ladies have a good grasp of things.

If I took any more meds there would be no room for food.

If I took any more meds there would be no room for food.

(Source: spooniestrong)

aligra-mace:

shadowlafox:

stop-hammerkind:

oh my god that’s so cute„

I can never not reblog.

*whispers* and now destroy every thing they love

(Source: iyimibole)

politicalmachine:

36 Photos From Russia That Everyone Needs To See

Russia is hosting the 2014 Olympic games in Sochi. What does this mean for gay athletes and spectators? Is the U.S. Olympic Committee okay with this?

be grateful for your pain as you walk down the street; that pain, it shows you you’re alive—and you’re most certainly alive—so be grateful for what the pain is telling you, ripping through you like a chainsaw and making you wish you were dead instead.

- Daphne Gottlieb (via thecityhorse)

flaresof-fibro:

asdfghjkl



Made me giggle.

flaresof-fibro:

asdfghjkl

Made me giggle.

(Source: 4gifs)

bedofproses:

scientists tell us that all water

is old water,

that there is no room for originality,

that everything is recycled.

the anguish of Achilles bleeding out

face-down in the Trojan dirt

mingles with that of a stockbroker caught

in the ebb and flow of the markets,

and what I am trying to say is that the tears

navigating south through the canyons on your face

may have once wet the cheeks

of Alexander the Great

for the same reason.

scienceyoucanlove:

Yale School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease, they report in the September 4 issue of the journal Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain damage that mimics the disease.“What is very exciting is that of all the links in this molecular chain, this is the protein that may be most easily targeted by drugs,” said Stephen Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study. “This gives us strong hope that we can find a drug that will work to lessen the burden of Alzheimer’s.”Scientists have already provided a partial molecular map of how Alzheimer’s disease destroys brain cells. In earlier work, Strittmatter’s lab showed that the amyloid-beta peptides, which are a hallmark of Alzheimer’s, couple with prion proteins on the surface of neurons. By an unknown process, the coupling activates a molecular messenger within the cell called Fyn.In the Neuron paper, the Yale team reveals the missing link in the chain, a protein within the cell membrane called metabotropic glutamate receptor 5 or mGluR5. When the protein is blocked by a drug similar to one being developed for Fragile X syndrome, the deficits in memory, learning, and synapse density were restored in a mouse model of Alzheimer’s.Strittmatter stressed that new drugs may have to be designed to precisely target the amyloid-prion disruption of mGluR5 in human cases of Alzheimer’s and said his lab is exploring new ways to achieve this.http://scitechdaily.com/yale-scientists-discover-alzheimers-missing-link/
source 



To late for my grandmother but hopeful for others.  RIP Grandma Fan.  Miss you!

scienceyoucanlove:

Yale School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease, they report in the September 4 issue of the journal Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain damage that mimics the disease.

“What is very exciting is that of all the links in this molecular chain, this is the protein that may be most easily targeted by drugs,” said Stephen Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study. “This gives us strong hope that we can find a drug that will work to lessen the burden of Alzheimer’s.”

Scientists have already provided a partial molecular map of how Alzheimer’s disease destroys brain cells. In earlier work, Strittmatter’s lab showed that the amyloid-beta peptides, which are a hallmark of Alzheimer’s, couple with prion proteins on the surface of neurons. By an unknown process, the coupling activates a molecular messenger within the cell called Fyn.

In the Neuron paper, the Yale team reveals the missing link in the chain, a protein within the cell membrane called metabotropic glutamate receptor 5 or mGluR5. When the protein is blocked by a drug similar to one being developed for Fragile X syndrome, the deficits in memory, learning, and synapse density were restored in a mouse model of Alzheimer’s.

Strittmatter stressed that new drugs may have to be designed to precisely target the amyloid-prion disruption of mGluR5 in human cases of Alzheimer’s and said his lab is exploring new ways to achieve this.

http://scitechdaily.com/yale-scientists-discover-alzheimers-missing-link/

source 

To late for my grandmother but hopeful for others. RIP Grandma Fan. Miss you!
My basket! If I fits, I sits!

My basket! If I fits, I sits!